SPIRITUS: (04-17) A Monthly update from the Respiratory Technology team at the WIMR.

This is the April 2017 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

RespiTech Members in Nice, France. RDD Europe 2017

RespiTech Members in Nice, France. RDD Europe 2017

This month has seen members of the RespiTech group travel Antibes, France for RDD Europe. Mali, Larisa, Khanh, Paul and Daniela travelled to Nice to attend the conference. Mali and Larisa both presented posters on their work while Khanh was invited to give a *Posters on The Podium* talk on he in vitro respiratory model. Paul Chaired a session and fun was had by all at the social events (even the Lego Scientists enjoyed themselves!)

Meanwhile, back at base, The RespiTech group would like to welcome two new members to the team, Arianna Fallacara and Laura Busato, Ariana and Laura are PhD students from the University of Ferrara, will spend the next few months with the team working on innovative particulate therapies for upper and lower respiratory tract disorders. We also welcome back Amanda Chancellor this month who will continue undertaking a research internship with the group. Lastly, we would like to congratulate YY (Hui Xin Ong) this month for being appointed as an associate lecturer in Pharmacology. YY, will continue to work with Pharmacology developing the new Master of Medicine (PharmDev) Degree, while coordinating and managing her own research projects within the RespiTech group. Well done YY!

As always we give an update of publications by the group. This month Micelle Pozzoli had a paper accepted in Drug Development and Industrial Pharmacy. This paper focusses on nasal drug delivery and is part of a continued collaboration between UTS (Maria Sukkar) and the University of Parma (Fabio Sonvico). The paper is entitled " Development of a Soluplus/Budesonide Freeze-Dried Powder for Nasal Drug Delivery. Drug Development and Industrial Pharmacy" You can find a full list of RespiTech publications here

Lastly, we would like to say farewell to old members. This month Yang Chen, Alaa Tulbah and Valentina leave us. Valentina, returns to Ferrara to continue her Postdoc and Alaa returns to Saudi to take up her academic role their. Yang, one of the longest running members of the team, leaves us to take up an exciting new Postdoctoral position in at the University of Hertfordshire in the UK. You will be missed and are always welcome back. Of course we had quite a leaving party....:)

RespiTech Leaving party for Yang, Valentina and Alaa

RespiTech Leaving party for Yang, Valentina and Alaa

SPIRITUS: (03-17) A Monthly update from the Respiratory Technology team at the WIMR.

This is the March 2017 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

This month RespiTech members have attended a number of events. Of note, the Woolcock hosted the Annual Ann Woolcock Lecture of which a number of the RespiTech team attended. Mali, Alaa, YY, Larissa and Emilie spent a weekend at the TSANZ lung cell workshop in Canberra and Paul and Daniela attended the Australian Lung Foundation Dinner hosted in Parliament house. Giulia Ballerin was invited to present  at the ASM student competition and did an excellent job explaining how bacteria have secret personalities. Finally Paul attended the Farewell dinner for the Hon Jillian Skinner at the Great Hall, University of Sydney

RespiTech Members at the TSANZ cell workshop in Canberra .

As always, we say farewell to old colleagues and welcome new ones. This month Mariam Mamlouk returns from Maternity Leave to continue her PhD with the RespiTech group and Alaa Tulbah returns as a Postdoctorate Researcher. Also, Jesse Xu returns to undertake a PhD with the group. Jesse will be working on innovative therapies for lung cancer. Welcome back guys! 

April looks to be a busy month, with the RDD Europe upon us already and a number of social and work related events on the horizon. Don't forget to follow our Facebook and Twitter pages to keep up-to-date with all RespiTech activities.

Annual Ann Woolcock Lecture | March 2017

SPIRITUS: (02-17) A Monthly update from the Respiratory Technology team at the WIMR.

Feb17

This is the February 2017 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

February has seen the commencement of a number of initiatives. Of note, the construction work for the Centre for Lung Cancer Research got underway at the Woolcock. This initiative, for which Paul has been a one of the key leaders, will result in a state-of-the-art research centre for people working in the area of lung cancer research and provide support for a the wider Lung Cancer Research Network.

Also this month, members of the RespiTech group successfully launch a new degree through the School of Medicine. The new Master of Medicine (PharmDev) degree is targeted at individuals working in the medical device and pharmaceutical sectors and offers professional education with respect to the development, registration and production of medicines in Australia and overseas. The Course coordinators for the new degree are Hui Xin Ong (YY), Paul Young and Daniela Traini. You can learn more about the degree here. Also this month, the same team members, traveled up to Brisbane to meet with Prof Scott Bell (QIMR) and a number of other collaborators to establish a new clinical trial in Cystic Fibrosis. The trial will aim to reduce burden of disease through similar and more efficient respiratory therapy.

SPIRITUS: (01-17) A Monthly update from the Respiratory Technology team at the WIMR.

Jan17

This is the January 2017 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. As 2017 begins the RespiTech group members begin to ramp up their research program for the new year. Firstly we welcome new members and say goodbye to old members. We say goodbye to Priyanka Shahani who has spent a short stay with the group undertaking a summer scholarship program working in the area of dry powder surface modification for controlling aerosol performance. We also welcome Sandra Grisales, who joins us as a new research assistant. Sandra will work with the group developing innovative microbiology models for the development of innovative anti-fungal formulations for respiratory disorders. 

This month we congratulate Jesse Xu and Mic for awards of their degree. Jesse, undertook a Pharmacology Hons with the group in 2016 focused on receptor expression in the airways and Mick completed his masters degree looking at dry powder formulation and performance enhancing excipients. Well done guys! 

As usual we give an update of publications from the group. This month members of RespiTech had three papers accepted. The first was via a Monash/UK/Sydney collaboration and was accepted in Pharmaceutical Research. The article "Revealing pMDI spray initial conditions: Flashing, atomisation and the effect of ethanol". takes a fundamental look at aerosol plume generation using synchrotron X-ray phase contrast imaging and quantitative radiography. The lead author was Nicholas Mason-Smith at Monash. The second paper was accepted in Clinical Science and was a collaboration with UNSW. The paper was entitled "Allergic environment enhances airway epithelial pro-inflammatory responses to rhinovirus infection". Dr Cristan Herbert from UNSW was first author and Prof Rakesh Kumar was corresponding. The last publication accepted was authored by Mic Lau and focussed on "Co-milled API-Lactose systems for inhalation therapy: impact of magnesium stearate on physico-chemical stability and aerosolization performance" The article was accepted in Drug Development and Industrial Pharmacy.

You can learn more about our publications here and social activities here and here.

SPIRITUS: (12-16) A Monthly update from the Respiratory Technology team at the WIMR.

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This is the December 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. December has been a month of celebrations for the RespiTech team. 

Firstly, the RespiTech group held their annual Christmas party and invited along some close collaborators to enjoy the celebrations. Dr Susan Hoe, an ex-PhD/Postdoc also joined joined us as she was visiting from the US. The group also celebrated the departure of Carola Cravedi and Cristina  Pacciana, who will tour Australia briefly before returning to Italy to finish their degrees'. You are always welcome back guys! The group also attended the Woolcock's Christmas party in December to celebrate the end of the year. You can learn more about RespiTech social activities at our Facebook and Twitter pages.

As always we congratulate people for successful publications and awards. Michael Lau was the first author on a paper entitled "Investigation into the manufacture and properties of inhalable high dose dry powders produced by co-milling API and lactose with magnesium stearate" in AAPS PharmSciTech. You can learn more about our publications here. We also celebrated the graduation of Alaa Tulbah for her PhD in the official ceremony on the University of Sydney Campus.

Lastly, we celebrated the Wedding of Hui Xin Ong (YY) to Marcus in a ceremony in Malaysia. Daniela Traini, Paul Young, Yang Chen and Lily Daviskas attended the celebrations. 

RespiTech Christmas Party

Graduation of Alaa

The Wedding of YY

As we end the year the RespiTech group are looking forward to the Summer break. We wish everyone a happy vacation and prosperous new year!

SPIRITUS: (11-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the November 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. November has been a busy month for the RespiTech group. Firstly, Daniela and Paul traveled to India to attend RDD Asia. Daniela presented a podium presentation on Innovation in therapeutics for the treatment of multi-drug resistant tuberculosis; basing her talk on some great tunes by Tina Turner, Tom Jones and The Beetles! Paul Chaired a session on the evolution and mechanics of spray formation from pressurised systems. Back at home the Group attended a conference on COPD, hosted by the Woolcock Emphysema Centre. Daniela and Hui Xin (YY) presented. 

RDD ASIA 2017

Also this month, Prof Traini was given a Established Scientists Award. The award, presented by the Royal Society will see Daniela attend the Commonwealth Science Conference in Singapore during 2017. During November, Pharmaxis made a press release announcing their partnership with the RespiTech group at the Woolcock to undertake a clinical trial in CF using the Orbital device. You can learn more about this press release here.

Lastly we give an update of Journal publications from the group. Maliheh Ghadiri was the first author on a paper accepted in the Journal of Drug Targeting. The paper entitled "The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells" is part of a collaboration with Pharmaxis and the Woolcock Cell Biology Group. The second paper entitled " Resveratrol solid lipid microparticles as dry powder formulation for nasal delivery, characterization and in vitro deposition study." is part of an ongoing collaboration with Prof Scalia at the University of Ferrara. Isabella Martignoni was the first author. You can find more about the groups publications here.

SPIRITUS: (10-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the October 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

October has been a busy month for the RespiTech Team. Firstly, the group had a RespiTech Wedding with the marriage of YY (Hui Xin Ong) to Marcus Chen. A number of the group attended the wedding in the Rocks, which was a fantastic venue and wonderful sunny afternoon event overlooking the Opera House and Bridge. Congratulations guys! Also this month, the group celebrated Wing-Hin Lee and Judy Loo’s time with the team in Sydney. Wing and Judy have been key leaders in the RespiTech group over the past years and sadly, are now leaving us to return to Malaysia to take the next step in their careers. The group hosted a farewell dinner at the Woolcock. 

Amanda Chancellor, an intern student also left the group this month after spending time with the group gaining valuable work experience. At the same time, Claudia Brown, a Pharmacy student from the University of Bath joins us to undertake a project on nasal drug delivery for the next few months.

A number of the group presented this month. Anthony Nedanoski and Jesse Xu both gave their Hons thesis presentations in Engineering and Pharmacology, respectively. Both have now submitted their final thesis. Subsequently, we say farewell to Anthony and wish you all the best (you are always welcome back to undertake a PhD!). Jesse Xu continues with us over the summer as he has been awarded a Sydney Medical School Summer Scholarship award. Congratulations! Also, Emelie Britt Linnea Land gave a talk this month at the Woolcock Seminar series. 

Later in the month the whole group attended Drug Delivery Australia, where a number of the team presented posters. David Cipolla from Aradigm also attended and spent time with the group  planning the recently commenced ARC Linkage program that we jointly hold.

 

The team have received a number of awards this month. Firstly, Giulia Ballerin was selected for a best poster award at DDA and gave an oral presentation along with 9 other contestants. Giulla won best presentation and was given a $1000 bursary to attend the Controlled Release Society annual meeting in the USA in 2017. Secondly, Daniela Traini was awarded a prestigious Endeavour Executive Fellowship to spend time establishing industry focussed relationships and research programs in San Francisco during 2017. The award, worth up to $20,000 will be used to spend time at the Pharmaceutical Company, Aradigm, in the Bay area. The award welcomes Daniela to the global Endeavour Alumni Network. Lastly, Paul Young and Daniela Traini were awarded a National Health and Medical Research Development Grant for $421,545 to conduct a clinical trial using a novel high-dose inhalation dry power device containing an antibiotics for the rapid treatment of infection in cystic fibrosis therapy. The grant is with Professor Scott Bell  at QHealth Research in Queensland and Pharmaxis Ltd based at Frenches Forest, Sydney.

At the Institute, the whole RespiTech group have now relocated offices from Level 3 to Level 6 of the Institute. This was necessary to make way for the construction of the new Centre for Lung Cancer Research that Paul has been driving. At the same time, upgrades to facilities in the RespiTech labs have been ongoing and the group have now installed a forth dedicated HPLC system and have taken delivery of a new electrical cell impedance sensing system that will allow real-time monitoring of cell response to stimuli.

Off-site, Daniela, YY, and Paul launched a brand new postgraduate degree with the Sydney Medical School. The Master of Medicine (PharmDev) is targeted at individuals working in the Pharma sector or graduate students looking to enter the industry by providing online continuing education in an innovative format. 

As always, we give an update on publications from the group. In addition to a number of conference abstracts, the group had one article accepted in Expert Opinion On Drug Delivery. The article by Wing is entitled ‘The achievement of ligand-functionalized organic/polymeric nanoparticles for treating multidrug resistant cancer.’

You can learn more about our publications here, competitive grants here and social activities on Facebook here and Twitter here.

October 2016 Photo highlights

SPIRITUS: (09-16) A Monthly update from the Respiratory Technology team at the WIMR.

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This is the September 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

At the start of September, Paul and Daniela visited the Institute for Biomedical Technologies at Auckland University of Technology to establish new collaborations. Paul gave a departmental seminar on “Innovation In Respiratory Technology At The Woolcock” and both had a chance to catch up with an old friend from their PhD days back in Bath. Around the same time Hui Xin Ong traveled to Kuala Lumpur where she gave an invited presentation at Pharma+Bio Asia 2016.

Daniela an Hui Xin received a grant from the Bosch Institute for a $13,000 rotary cell culture system. The system will be used by the group and researchers in the Bosch Institute to develop 3D cellular structures that can be used to realistically mimic complex cell structures. Continuing the 3D theme, the group invested in a new 3D printer this month. This is the second in-house system and expands the groups capability in terms of resolution and material choices. Specifically, this will give the group capability to print transparent devices, anatomical casts and devices using medically approved plastics.

Daniela, The Woolcock and the Italian Embassy also hosted the Italian Scientist Down Under Conference this month. The conference was for leading Italian Scientists within the region and was preceded by the the Chief Scientist of NSW and Science Attaché. Lastly but not least, the group celebrated Larissa’s birthday. October looks to be even busier, as we we have a number of initiatives underway and a number of exciting announcements to make.

SPIRITUS: (08-16) A Monthly update from the Respiratory Technology team at the WIMR.

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This is the August 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. This month have seen the return of a number of RespiTech team members. Michele Pozzoli returned from Italy after spending the past few months working at the University of Parma. Yang Chen returned from her visit to the Chiesi Innovation Centre in the UK and Larissa Gomes Dos Reis returned from her visit to Evonik in Darmstadt, Germany. Welcome home! We also welcome two new members of the group this month and say goodbye to another. Carola Cravedi and Cristina Pacciana join us from the University of Torino and University of Ferrara, respectively. Cristina is working on a project in the area of epithelia tight junction modification while Carola is working on a project in the area of inhaled chemotherapy treatments for lung cancer. Also, this month we say farewell to Yiwang Xu. Yawing, a medical trainee, has been visiting the group over the past month and now returns to the University of Cambridge to complete his studies. You are always welcome back Yiwang!

Also, this month, work started on the new RespiTech offices on level 6 of the Institute. These works, mark the first phase of the construction of the new Centre for Lung Cancer Research. The team expect to move up to their new offices in September so that construction work can commence on level 3 of the Institute.

The groups research was highlighted in a Channel 9 news report this month when the links between COPD and sleep disorders were discussed and the CIRCOMED study highlighted. CIRCOMED is a collaborative clinical study between Sleep, Lung Physiology and RespiTech departments, and aims to understand how COPD and sleep disorders are inter-related. The study has already commenced and patients recruited for studies at the Institute’s clinic.

On a social side of things, members of the group participated in the Institute’s open day in celebration of National Science week. The Institute hosted 100 guests from local schools and the community, to give them an insight into the work we do in sleep and breathing research. Participants got to see how RespiTech research is conducted and had live demonstrations of 3D printing, particle engineering and other fun technologies.

RespiTech participate in National Science Week

Paul and Daniela attended the SPAM celebrations and drinks. SPAM, conceived by Prof Daniela Traini, Penny Oxford and Prof Fiona White, supports promotion of senior women academics  at the University. Paul and Daniela also attended the Woolcock Board’s farewell drinks for Board member Oliver Frankel.

Towards the end of the month, Paul and Daniela attended the New Zealand MedSci conference in Nelson, NZ. Paul, an invited speaker, gave a presentation on “Innovative Devices And Therapies For Respiratory Diseases”.

Lastly, the group had one paper accepted this month. Daniela Traini had a paper accepted with Philippe Rogueda in Expert Review of Respiratory Medicine. The paper was titled “The future of inhalers: how can we improve drug delivery in asthma and COPD?”.

SPIRITUS: (07-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the July 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. July has been a busy month for the group. During July Paul Young, Dany Traini, Yang Chen and Hui Xin Ong (YY) traveled overseas to the Chiesi 7th anniversary and innovation conference in the UK. YY gave a podium on “Teaching Old Drugs New Tricks” while Paul and Dany gave a double act presentation on ‘Industry vs. Academia’ Yang stayed behind after the conference to spend some time on secondment at Chiesi’s Innovation Centre in Chippenham. Meanwhile, Larissa Gomes Dos Reis, spent the month at Evonik, in Darmstadt Germany developing inhalable particles for vaccine delivery as part of her PhD. As always, the RespiTech lego scientists travelled with the group and had quite a fun time. You can learn more about the social aspects of the Lego scientists and that of the RespiTech group via our Facebook and Twitter accounts.


Back at home, Paul and Daniela attended the Airways 2016 Conference in Sydney sponsored by Boehringer Ingelheim. Paul gave a “Inhalation 101” lecture on pressurised metered dose inhalers while Dany gave a presentation on eCigs. As always, we welcome new members to the group. This month, the group welcomed two new team members. Xu Yiwang, a medical student from the University of Cambridge and Amanda Chancellor a Biomedical Engineering Student from the University of Sydney. Yiwang will undertake a project on alveolar macrophage function and response to stimulants while Amanda is undertaking work experience and working in the area of nasal drug delivery. Welcome! 

Lastly, the group published 4 articles this month. The first, published by Maliheh Ghadiri looked at the impact of fatty acids on tight junction permeability. The article was accepted in Pulmonary Pharmacology and Therapeutics and is titled “Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction”. The second paper was accepted in Drug Delivery Letters and is part of a collaborative program with Dr Bosnic-Anticevich. The paper is titled “Substitute and add-on devices used in inhalation therapy: is it safe to recommend replacing the Ventolin™ actuator with the Sports-Haler™”. The third paper was Larisa’s review article on

“Inhaled gene delivery: a formulation and delivery approach” accepted in  Expert Opinion on Drug Delivery. Lastly, the fourth paper accepted this month was Michele Pozzoli’s paper titled “Application of RPMI 2650 Nasal Cell Model to a 3D Printed Apparatus for the Testing of Drug Deposition and Permeation of Nasal Products” accepted in European Journal of Pharmaceutics and Biopharmaceutics. You can learn more about publications of the RespiTech group on our website here.

SPIRITUS: (06-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the June 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

June has been a busy month for the RespiTech team. Firstly, the group had their first RespiTech wedding. PhD student Stewart Yeung married Chloe and the RespiTech team attended the marriage and celebrations. Congratulation guys! Later in the month, the Woolcock and RespiTech team celebrated the 2015-16 graduations of a number of its members including Sharon Davis, Mali Ghadiri and Yang Chen. Sadly, the group said farewell to Sergio Gualtieri and Elvira Pisano who have returned to Italy to complete their degrees. You are always welcome back guys!

Wedding Team RespiTech

Away from the office YY (Hui Xin Ong) was invited to give a Plenary Talk at the Sydney Surfaces And Soft Stuff (SASSY 2016) conference held at UNSW. Meanwhile Paul represented the Institute at the annual Sydney Research meeting while Daniela gave an invited seminar at SCELCE at the National University of Singapore.

As always, we give an update on the groups publications. This month Yang Chen had a paper accepted in AAPS Pharm Sci Tech. The paper titled “High-Speed Laser Image Analysis of Plume Angles for Pressurized Metered Dose Inhalers: The Effect of Nozzle Geometry” is part of an ongoing collaboration with David Fletcher in Engineering and David Lewis’s team at Chiesi in the UK.

Next month sees numerous members of the group travelling overseas for meetings and conferences. Time for the Lego Scientists to pack their bags.

SPIRITUS: (05-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the May 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research.

In May, members of the RespiTech group were awarded an Australian Research Council linkage grant. Daniela Traini and Paul Young were awarded the grant, worth $420,000, to develop innovative nanotechnologies that target biofilms. Biofilms occur everywhere in nature and act as a protective matrix for aggressive bacteria and fungus that can effect our health, food production, processing machinery and water quality. The Linkage grant is in partnership with Aradigm Corporation based out of San Fanscisco. 

Also this month the group had a number of celebrations. These included the celebration of  Maree Svolos birthday, dinner to celebrate Alaa’s PhD award and a group outing for an evening of Karaoke in the City.

The great kareookee caper

As usual, the group give an update of publications. This month, members of the group published 5 research articles. The First titled ‘From Single Excipients to Dual Excipient Platforms in Dry Powder Inhaler Products’ was a review accepted in International Journal of Pharmaceutics. The paper was a collaborative effort of the old Bath crew with Jag Shur (first author) Rob Price (corresponding) Dave Lewis, Paul Young and Stephen Edge. The second paper titled 'Primary Air Liquid Interface Culture of Nasal Epithelium for Nasal Drug Delivery' was accepted in Molecular Pharmaceutics. The paper by YY (Hui Xin Ong), is the result of her collaborative research program with Prof Joy Conway and the University of Southampton. Also, this month in a third paper titled “Could simvastatin be considered as a potential therapy for chronic lung diseases?” was published. In this paper, Alaa Tulbah gives an expert opinion on the future of inhaled statin therapy. The fourth paper, accepted in Current Drug Delivery is the result of a collaboration between Prof Rafael Villalobos from the University of Mexico and the RespiTech team. The paper is titled 'Drug release from inert spherical matrix systems using Monte Carlo simulations'. Lastly, the team published a paper with David Lewis and the group at Chiesi’s UK innovation Centre. The paper titled 'Exploring the impact of sample flowrate on in vitro measurements of metered dose inhaler performance' was accepted in International Journal of Pharmaceutics.

RespiTech Team awarded ARC Grant to develop nanotechnologies for targeting biofilms.

Professors Daniela Traini and Paul Young were awarded an Australian Research Council grant to develop innovative nanotechnologies that target biofilms. Biofilms occur everywhere in nature and act as a protective matrix for aggressive bacteria and fungus that can have an effect on our health and impact on food production, processing machinery and water quality. The Linkage grant worth $420,000 is in partnership with Aradigm Corporation (USA). 

Biofilm targeting nanoparticleS

Biofilm targeting nanoparticleS

The linkage team will develop nano-particulate systems based on a single platform technology that can be used to treat both bacterial and fungal biofilms for numerous applications. The current lack of a suitable formulation and delivery system hinders the eradication of fungal and bacterial biofilms from surfaces. These new systems will have enhanced residency time, penetration properties and effectiveness in biofilms. This project intends to understand the properties that govern the formation and interactions in these systems, and develop in-vitro tools that the wider scientific community can use. The project expects to generate a single platform that can be used for the eradication of biofilms in numerous applications, from healthcare to agriculture.

SPIRITUS: (04-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the April 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. During April the team attended Respiratory Drug Delivery in Arizona. Daniela, Paul, YY, Larissa and Michele presented an update of research from the group. The group had 4 peer reviewed full-conference abstracts accepted for publication. In addition,  Larissa Gomes was invited to give a poster on the podium presentation on her work in respiratory vaccine drug delivery space, while Paul gave a podium presentation on the mysteries of lactose and the meaning of life. 

 

RespiTech at RDD2016

 

RespiTech Celebrations during April 2016

Back at home the group celebrated Yang Chen’s PhD graduation -Well done Dr Yang! We also said farewell to Marie Hellfritzsch, who returns to the University of Kiel after spending the past few months with our group working on a collaborative project in the area of nano-technology. You can learn more about the social aspects of the RespiTech group via our Facebook page or Twitter pages.

As always, the group give an update of their publications. This month the group had one publication accepted in the International Journal of Pharmaceutics entitled ‘The development of a single-use, capsule-free multi-breath tobramycin dry powder inhaler for the treatment of cystic fibrosis.’ Details of this publication along with all others from the RespiTech group can be found on our publications page.


SPIRITUS: (03-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the March 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. During March, a number of RespiTech people have graduated during official ceremonies in both Australia and Italy. Mali Ghadiri graduated with a PhD from the Faculty of Pharmacy at The University of Sydney. Valentina Trotta graduated with a PhD from the Faculty of Medicine at the University of Sydney and The Faculty of Pharmacy at the University of Ferrara (Italy). Beatrice Zanelli graduated with a Bachelor in CTF (being awarded 110/110 cum laude). Many congratulations to all! This month we also celebrated Elvira’s birthday and the return of Dany from her overseas trip to Italy. You can learn more about social aspects of the group via our Facebook page and Twitter account (don’t forget to like and follow!)

As always we welcome new members of the group and say goodbye to old members and visitors. This month we say farewell to Regina Scherließ who has spent the last month with us on a short-term sabbatical from the University of Kiel. The visit was a great success and we have a number of new and exciting projects underway. Regina, you are always welcome back, hopefully on a longer sabbatical next time.

Lastly, we give an update on publications. This month the group had a paper accepted in RSC advances. The paper, authored by Sumit Arora is entitled “Investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy.” Well done Sumit! You can learn more about our publications here.

Mali, Valentina and Beatrice graduations | March 2016

SPIRITUS: (02-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the February 2016 newsletter from the RespiTech Group at the Woolcock Institute of Medical Research. During this month, Dr Regina Scherließ from the University of Kiel visited us on sabbatical. Regina was awarded a University of Sydney international collaboration award to establish a number of joint projects in the area of controlled drug delivery to the respiratory tract. She is co-supervising Marie Hellfritzsch. Welcome Regina!

Daniela Traini, left for a visit to the University of Ferrara in February. Dany and the RespiTech team have a long-running collaboration and exchange of students with both Prof Santo Scalia and A/Prof Gaia Colombo from Ferrara. Dany will spend 4 weeks discussing new projects, giving lectures and sitting on a PhD commission panel. We also say farewell David Lewis and Allan Tweedie who visited us briefly. David and Alan co-supervise Mic and Stewart. The visit was focussed on catching up regarding current and future projects for the next year..

February also saw the arrival of two new honours students, Anthony Nedanoski and Jesse Zhe Yi Xu. Over the next year Anthony will undertake a research project in the area of CFD with a focus on simulation of the nasal geometry for drug delivery. Jesse is undertaking a research project on transmembrane proteins in the respiratory tract and developing a number of models to study them. 

Lastly, the group had 2 journal articles accepted this month. the first by Valentina entitled ‘Co-spray dried resveratrol and budesonide inhalation formulation for reducing inflammation and oxidative stress in rat alveolar macrophages’ was accepted in the European Journal of Pharmaceutical Sciences. The second by Michele, entitled ‘Dry Powder Nasal Drug Delivery: Challenges, Opportunities and a study of the commercial Teijin Puvlizer Rhinocort® device and formulation’ was accepted in Drug Development and Industrial Pharmacy. Well done all! You can learn more about our publications here.

 

group photo feb 2016 (with DAVE and ALAn)

 

SPIRITUS: (01-16) A Monthly update from the Respiratory Technology team at the WIMR.

This is the first newsletter for 2016 from the RespiTech Group at the Woolcock Institute of Medical Research. The group has now been operational for 3 years and we have achieved significant successes. As always the group have prepared an annual report for 2015 which you can read via the direct 2015 report link here. You can also look at the previous reports via RespiTech.org reports page  

January marks the commencement of our fourth year and as people have returned from the summer vacation things have began to ramp up. Firstly, David Lewis and Alan Tweedie from Chiesi UK visited in January to discuss and focus on a number of projects that we are running in collaboration. With this visit and a number of birthdays in January (Sjoerd Zonings and Lala Sarkissian) the group found plenty of time to celebrate. You can learn more about social aspects of the group via our Facebook page and Twitter page (don’t forget to like and follow us!)

As always we welcome new researchers to the group and say farewell to old colleagues. Firstly we say goodbye to both Sjoerd Zonings and Rafael Villalobos García. Sjoerd has spent the second part of 2015 with us undertaking a research program looking at advanced excipients for controlling handling of carrier based DPIs during manufacture and filling. Sjoerd returns to the Netherlands to finish his degree. Rafael has been here on sabbatical for the past 6 months working on a collaborative project in the area of counter simulation for controlled release inhalation systems. He will return to the University of Mexico. You are always welcome back guys! 

We would like to welcome new visiting research scientists: Elvira Pisano and Sergio Guiltier from the University of Ferrara (Italy) and Marie Hellfritzsch from the University of Kiel (Germany). Sergio is working on a project in the area of carrier based dry powder inhaler drug delivery, Elvira on a project focused on controlled release in the lung and Marie on advanced microparticles for nasal targeting. Welcome all!

We also give an update on peer-reviewed publications from the group. This month, the group published one article, accepted in Pharmaceutical Research. The paper is a multi-institute collaborative project, which Nicholas Mason-Smith being the lead author from Monash. The paper entitled: ‘Insights into spray development from metered-dose inhalers through quantitative X-ray radiography’ utilises a synchrotron to evaluate the evolution of sprays from metered dose inhalers. Learn more about our publications here.

Year 4 looks to be an exciting year for RespiTech!.

SPIRITUS: (12-15) A Monthly update from the Respiratory Technology team at the WIMR

This is the final news letter for 2015 from the RespiTech Group at the Woolcock Institute of Medical Research. 

2015 RespiTech Christmas Cook-up

In December members of the group celebrated the festive season with their annual Christmas party. Members and friends of RespiTech attended and even Santa made a appearance. You can learn more about the party and other social events via our Facebook page and Twitter feed. Shortly after the celebrations, Yang, Jess and Sumit attended Drug Delivery to the Lungs Conference in Edinburgh. Sumit Arora was selected for the New Investigator Presentation and, later during the conference, was awarded the Pat Burnell Young Investigator Award for his presentation and research. Well done Sumit! 

Meanwhile, Paul and Daniela visited collaborators in Europe. Daniela gave a series of lectures at the University of Perugia  (Italy) and Paul gave a series of seminars on innovation at the Woolcock and the future of respiratory drug delivery.

As always, we give an update of publications and grants. In December the group published one paper with Mariateresa Stigliani as the first author. The paper entitled ‘Antibiotic Transport Across Bronchial Epithelial Cells: effects of Molecular Weight, LogP and Apparent Permeability’ was accepted in European Journal of Pharmaceutical Sciences. Also in December, Daniela was awarded a $61,000 NHMRC USyd Equipment grant for a Real-time bio impedance measurement system. This state-of-the-art system will be used to monitor cellular permeability in realtime when epithelia are treated with drugs or affected by local pathogens. You can learn more about all our journal publications here and grants here.

This month we also say farewell to Fin Canney, who has spent the last few months with the group undertaking a project looking at tight junction modification in lung epithelia. Fin is a Pharmacy Student from Bath (UK) and will return to complete his Degree in January. All the best Fin!

Lastly, the RespiTech group would like to congratulate Daniela Traini who was appointed to Full Professor in December. Daniela’s new title will be ‘Professor of Respiratory Science’ at the University of Sydney. Fantastic news!

2015 has been an exciting and productive year and as we look forward to exciting opportunities in 2016. We wish all our collaborators and followers a happy and productive 2016.

 
 

SPIRITUS: (11-15) A Monthly update from the Respiratory Technology team at the WIMR

Nov 2015.jpg

This is our November update and penultimate news letter from the RespiTech for 2015. This month, members of the group attended Drug Delivery Australia in Brisbane. Paul gave a presentation on innovations in drug delivery and Daniela on repurposing oral drug delivery molecules for inhalation. Lala, Michele, Alaa and Mariam had posters, while Mariam was selected for a posters on the podium presentation to highlight the clinical work she is conducting in Cystic Fibrosis Research.

As always, we congratulate people for their achievements and give an update on publications from the group. Firstly, YY was awarded a University Kick Starter grant. The Kickstarter grant, worth $30,000 will be used to develop ‘Innovative inhaled antibiotic treatment strategies for the eradication and prevention of persistent respiratory infections’. Also this month, Paul was appointed as the new incoming President of The Australian Chapter of the Controlled Release Society (AUS-CRS). AUS-CRS was established in 2007, with the aim of providing a forum for science and education for Australian scientists with an interest in delivery of bioactives. You can learn more about AUS-CRS here. Later in month, Daniela received $30,000 in a NHMRC near-miss funding towards a large multidisciplinary project that will evaluate repurposing a number of small molecules for lung diseases.

The RespiTech group published five peer reviewed papers this month. The first, an original research article by Sumit Arora in ‘Expert Opinion on Drug Delivery’ was titled ‘Highly Respirable Dry Powder Inhalable Formulation of Voriconazole with Enhanced Pulmonary Bioavailability’. This work focusses on respiratory fungal infection and inhalable antifungal treatment. The second paper by Sharon Davis, focused on health-care provision, was accepted in International ‘Journal of Clinical Pharmacy’. This article is titled ‘Knowledge that people with intellectual disability have of their inhaled asthma medications-messages for pharmacists’. Third, the group had a paper accepted with their collaborators at Monash University and Chiesi UK in ‘Pharmaceutical Research’. The paper (first author Daniel Duke) is titled ‘Temporally and spatially resolved x-ray fluorescence measurements of in-situ drug concentration in metered-dose inhaler sprays’ is based on a synchrotron study of the evolution of pMDI sprays. The fourth paper this month was a review article, authored by Maliheh Ghadiri looking at treatment options for Interstitial Pulmonary Fibrosis (IPF). The article accepted in the journal ‘Expert Opinion on Biological Therapy’ is titled ‘Cell-based therapies for the treatment of idiopathic pulmonary fibrosis (IPF) disease’. Lastly, a paper authored by Judy Loo was accepted in the ‘Journal of Agricultural and Food Chemistry’ This study investigated the combination of silver ions and nano-particle flavonoids for reducing bacterial colonisation in respiratory infections. The paper is titled ‘Combination of Silver Nanoparticles and Curcumin Nanoparticles for Enhanced Anti-biofilm Activities’

Well done all!. To learn more about these and other publications from the Respiratory Technology group you can visit our publications page here.

Lastly, the group began to ramp up celebrations for the festive season. This began with the Melbourne Cup day celebrations in November. December will have more celebrations as well as a number of the group traveling overseas for meetings and conferences. You can learn more about these and other activities of the group via Facebook and Twitter.

YY awarded $30,000 Kick Start Grant

Dr Hui Xin Ong (YY) recipient of 2016 KickStarter GRANT

Dr Hui Xin Ong (YY) recipient of 2016 KickStarter GRANT

Congratulations go to YY (Hui Xin Ong) who was awarded a Sydney Medical School Kick Start Grant this month. 

YY will utilise the funding to establish a project on Innovative inhaled antibiotic treatment strategies for the eradication and prevention of persistent respiratory infections. Specifically, The project will explore different novel anti-biofilm agents for patients suffering from chronic lung infections.

The Kickstart Grants Program is a partnership between the University of Sydney and the Balnaves Foundation for investing in people and pilot projects that are likely to lead to external funding returns for the Sydney Medical School and the University of Sydney in the future (you can learn more about the scheme here)