Due the significant difficulty in developing inhalation medicines, the mechanism of dissolution and uptake after deposition in the lung is poorly understood. One of the key research focuses for the Respiratory Technology Team is to develop cell based models for studying deposition and uptake of 'real' particle systems at the lung interface. This area of research has major implications in the area of bioequivalence and mechanistic understanding.
The group is focused on applying healthy and diseased-based models, co-cultured systems and advanced monitoring techniques. These methods are also being developed in parallel with conventional non-cell based techniques and correlated with clinically relevant data.